Studying RNA at the Host-Virus Interface.

WE STUDY VIRUSES THAT POSE A THREAT TO THE HEALTH OF BILLIONS OF PEOPLE AROUND THE GLOBE.

Hepatitis C virus, Dengue, and Zika viruses are positive-sense RNA viruses of the Flaviviridae family. Our lab uses state-of-the art molecular biology, biochemistry, and high-throughput approaches to investigate RNA-RNA and protein-RNA interactions important for regulation of viral gene expression, replication, immune evasion, and pathogenesis. Our research will aid in improving our understanding of how these positive-sense RNA viruses usurp the host cell, replicate their genomes, and cause disease. We hope to gain insight into RNA regulation and identify novel avenues for antiviral intervention.