Cousineau SE, Camargo C, and Sagan SM*. Poly(rC)-Binding Protein 2 Does Not Directly Participate in HCV Translation of Replication, but Rather Modulates Genome Packaging (2024) Viruses 16:1220.

Quinn H. Abram, Breanna N. Landry, Alex B. Wang, Ronja F. Kothe, Hannah C.H. Hauch and Selena M. Sagan*. The myriad roles of RNA structure in the flavivirus life cycle. (2024) RNA Biol 21(1): 14-30.

Rachel S. Hayes, Ahmed K. Oraby, Carolina Camargo, David J Marchant* and Selena M. Sagan*. Mapping respiratory syncytial virus fusion protein interactions with the receptor IGF1R and the impact of alanine-scanning mutagenesis on viral infection. (2024) J Gen Virol 105(1).

Barnard TR, Landry BN, Wang AB and Sagan SM*. Zika virus NS3 and NS5 proteins determine strain-dependent differences in dsRNA accumulation in a host cell type-dependent manner (2023). J Gen Virol. 104(6).

Naderi S, Chen PE, Murall CL, Poujol R, Kraemer S, Pickering BS, Sagan SM*,
and Shapiro BJ*. Zooanthroponotic transmission of SARS-CoV-2 and host-specific viral mutations revealed by genome-wide phylogenetic analysis (2023). eLife 12:e83685.

Rheault M, Cousineau SE, Fox DR, Abram QH, and Sagan SM. Elucidating the distinct contributions of miR-122 in the HCV life cycle reveals insights into virion assembly (2023). Nucleic Acids Res. 51(5):2447-2463.

Sagan SM and Weber SC. Let’s phase it: viruses are master architects of biomolecular condensates (2022). Trends in Biochemical Sciences. 48(3):229-243.

Barnard TR, Wang AB, and Sagan SM. A highly sensitive strand-specific multiplex RT-qPCR assay for quantitation of Zika virus replication. (2022) J Virol Meth. 307:114556.

Cousineau SE, Rheault M, and Sagan SM. Poly(rC)-binding protein 1 limits hepatitis C virus virion assembly and secretion. (2022) Viruses 14(2):291.

Chahal J, Gebert LFR, Camargo C, MacRae IJ, and Sagan SM*. miR-122-based Therapies Select for Three Distinct Resistance Mechanisms Based on Alterations in RNA Structure. (2021) PNAS USA. Aug 17; 118(33):e2103671118.

Heirwegh E, He J, MacLean E, Kamhawi S, Sagan SM, and Olivier M. Sandfly Fever Sicilian Virus-Leishmania major co-infection modulates innate inflammatory response favoring myeloid cell infections and skin hyperinflammation. (2021) PLoS Negl Trop Dis. Jul 26; 15(7):e0009638.

Safiabadi Tali SH, LeBlanc JJ, Sadiq Z, Oyewunmi OD, Camargo C, Nikpour B, Armanfard N, Sagan SM, Jahanshahi-Anbuhi S. Tools and techniques for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/COVID-19 Detection. (2021) Clin Microbiol Rev. 34(3):e00228-20.

Camargo C, Lupien A, McIntosh F, Menzies R, Behr M, and Sagan SM*. Effectiveness of Germicidal Ultraviolet light to inactivate coronaviruses on personal protective equipment to reduce nosocomial transmission. (2021). Infect Control Hosp Epidemiol. 21:1-6.

Cordeiro B, Jeon P, Boukhaled GM, Corrado M, Lapohos O, Roy DG, Williams K, Jones RG, Gruenheid S, Sagan SM, and Krawczyk CM. MicroRNA-9 Fine-Tunes Dendritic Cell Function by Suppressing Negative Regulators in a Cell-Type-Specific Manner. (2020) Cell Rep. 31(5): 107858.

Barnard TR, Abram QH, Lin QF, Wang AB, and Sagan SM. Molecular Determinants of Flavivirus Virion Assembly. (2021) TRENDS Biochem Sci. 46(5):378-390.

Cousineau S, Erman A, Liu L, Saeed S, Fradette L, Feld JJ, Grebely J, MacParland SA, Shoukry NH, Sebastiani G, and Sagan SM on behalf of the Canadian Network on Hepatitis C (CanHepC). The 8thCanadian Symposium on Hepatitis C virus “Improving diagnosis and linkage to care”. (2020) Can Liv J. 3(1): 3-14.

Van Vlymen JM, Magnus J, Jaeger M, Breton S, Taylor NG, Phelan R, and Sagan SM. Hepatitis C Contamination of Medication Vials Accessed with Sterile Needles and Syringes. (2019) Anesthesiology. May 30 [Epub ahead of print].

Chahal J, Gebert LFR, Gan HH, Camacho E, Gunsalus KC, MacRae IL, and Sagan SM. miR-122 and Ago interactions with the HCV genome alter the structure of the viral 5' terminus. (2019) Nucleic Acids Res. Apr 3. In press.

Bernier A and Sagan SM. Beyond sites 1 and 2, miR-122 target sites in the HCV genome have negligible contributions to HCV RNA accumulation in cell culture. (2019) J Gen Virol. 100(2): 217-226.

Barnard TR, Rajah MM, Sagan SM. Contemporary Zika virus isolates induce more dsRNA and produce more negative-strand intermediate in human astrocytoma cells. (2018) Viruses. 10(12):E728.

Canuti M, Williams C, Sagan SM, Oude Munnink BB, Gadi S, Verhoeven JTP, Cotton M, Lang AS, Cullen J and van der Hoek L. Virus discovery reveals a high prevalence and a great diversity of members of the Flaviviridae in wild lemurs. (2018) Arch Virol. Nov 20.

Juzwik CA, Drake S, Lécuyer M, Morquette B, Zhang Y, Charabati M, Sagan SM, Bar-Or A, Prat A, Fournier A. Neuronal microRNA regulation in Experimental Autoimmune Encephalomyelitis. (2018) Scientific Reports. 8(1):13437. 

Bernier A and Sagan SM. The diverse roles of microRNAs at the host-virus interface. (2018) Viruses. 10(8):E440

Cheng ML, Abdel-Hakeem MS, Cousineau SE, Grebely J, Marshall AD, Saeed S, Sagan SM, Shoukry NH, Feld JJ and MacParland SA. The 7th Canadian Symposium on Hepatitis C Virus: “Toward Elimination of HCV: How to Get There”. (2018) Canadian Liver Journal. 1(3): 139-152.

Breton S, van Vlymen J, Xia S, Holden R, Phelan R, Sagan SM, And Jaeger M. Medication preparation and administration practices among Canadian Anesthesiologists. (2018) Can J Anaesth, 65(10): 1100-1109.

Amador-Cañizares Y, Bernier A, Wilson JA, Sagan SM. miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5’ end from the cellular pyrophosphatases, DOM3Z and DUSP11. (2018) Nucleic Acids Research. 46(10): 5139-5158.

Alpuche-Lazcano SP, McCullogh CR, Del Corpo O, Rance E, Scarborough RJ, Mouland AJ, Sagan SM, Teixeira MM, and Gatignol A. Higher cytopathic effects of a Zika vrus Brazilian isolate from Bahia compared to a Canadian-imported Thai strain. (2018) Viruses. 10(2):E53.

Khan S, Bernier A, Dapp D, Fortier E, Krajden M, King A, Grebely J, Sagan SM, Cooper CL, Crawley AM. 6th Canadian Symposium on HCV: Remaining battles in delivering HCV care in the highly curative DAA era. (2018) Canadian Liver Journal. 1(2):94-105.

Pardy RD, Rajah MM, Condotta SA, Taylor NG, Sagan, SM and Richer MJ. Analysis of the T Cell Response to Zika Virus and Identification of a Novel CD8+ T Cell Epitope in Immunocompetent Mice (2017) PLoS Path. 13(2): e1006184.

Rajah MM, Pardy RD, Condotta SA, Richer MJ and Sagan SM. Zika virus: Emergence, Phylogenetics, Challenges and Opportunities. (2016) ACS Infect Dis. 2(11):763-772. 

van Buuren N, Fradette L, Grebely J, King A, Krajden M, MacParland SA, Marshall A, Saeed S, Wilson JA, Klein MB, Sagan SM. The 5th Canadian Symposium on Hepatitis C virus: We’re Not Done Yet: Remaining Challenges in Hepatitis C. (2016) Can J Gastroenterol Hepatol. 60(4):2018-2027. 

Sarnow P and Sagan SM. Unraveling the Mysterious Interactions Between Hepatitis C Virus RNA and Liver-specific MicroRNA miR-122. Annual Review of Virology (2016) 3(1):309-332.

Izreig S, Samborska B, Johnson RM, Sergushichev A, Ma EH, Lussier C, Loginicheva E, Donayo AO, Poffenberger MC, Sagan SM, Vincent EE, Artyomov MN, Duchaine TF, Jones RG. The miR-17~92 microRNA Cluster is a Global Regulator of Tumor Metabolism. (2016) Cell Reports 16(7):1915-1928.

Sagan SM, Dupont B, Grebely J, Krajden M, MacParland S, Raven JF, Saeed S, Feld JJ, Tyrrell DL, and Wilson JA. Highlights of the Fourth Canadian Symposium on Hepatitis C: Moving Towards a National Action Plan. Can J Gastroenterol Hepatol. (2016) 2016:5743521, 11 pages.

Kulkarni AS, Damha MJ, Schinazi RF, Mo H, Doehle B, Sagan SM, and Götte M. A complex network of Interactions between S282 and G283 of Heaptitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin. Antimicrob Agent Chemother (2016) 60 (4): 2018-2027.

Sagan SM, Chahal J, and Sarnow P. cis-acting RNA elements in the Hepatitis C virus RNA genome. Virus Res (2015) S1068-1702(14):00543-7.

Flynn RA, Martin L, Spitale RC, Brian Do, Sagan SM, Zarnegar B, Qu K, Khavari PA, Quake SR, Sarnow P, and Chang HY. Dissecting non-coding and pathogen RNA-protein interactomes. RNA (2015) 21(1):135-143. 

MacParland S, Bilodeau M, Grebely J, Bruneau J, Cooper C, Klein M, Sagan SM, Choucha N, Balfour L, Bialystok F, Krajden M, Raven J, Roberts E, Russell RS, Houghton M, Tyrrell DL, Feld JJ, on behalf of the National CIHR Research Training Program in Hepatitis C. The Third Canadian Symposium on Hepatitis C: Expanding Care in the IFN-free Era. Can J Gastroenterol (2014) 28(9):481-487. 

Wilson JA and Sagan SM. Hepatitis C virus and human miR-122: insights from the bench to the clinic. Curr Opin Virol (2014) 7C:11-18.

Sagan SM and Sarnow P. RNAi in Mammalian Cells: Antiviral After All. Science (2013) 342(6155):207-208.

Cox EM, Sagan SM, Mortimer SA, Doudna JA, and Sarnow P. Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules. RNA (2013) 19(12):1825-1832.

Grebely J, Bilodeau M, Feld JJ, Bruneau J, Fischer B, Raven JF, Wong T, Roberts E, Choucha N, Myers RP, Sagan SM, Wilson JA, Bialystok F, Tyrrell DL, Houghton M, and Krajden M on behalf of the National CIHR Research Training Program in Hepatitis C. The Second Canadian Symposium on Hepatitis C Virus Infection: A Call to Action. Can J Gastroenterol (2013) 27(11):627-632.

Sagan SM, Sarnow P, and Wilson JA. Modulation of GB virus B (GBV-B) RNA abundance by microRNA-122: Dependence on and escape from miR-122 restriction. J Virol. (2013) 87(13):7338-7347. 

Machlin ES, Sarnow P, and Sagan SM. Combating Hepatitis C Virus by Targeting MicroRNA-122 Using Locked Nucleic Acids. Curr Gene Ther (2012) 12(4): 301-306.

Nasheri N, Pezacki JP, and Sagan SM. Design and screening of siRNAs against highly structured RNA targets. Methods Mol Biol (2013) 942: 69-86.

Machlin ES, Sarnow P, and Sagan SM. Masking the 5’ terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex. Proc Natl Acad Sci U S A (2011) 108 (8): 3193-3198.

Sagan SM, Nasheri N, Luebbert C, and Pezacki JP. The efficacy of siRNAs against Hepatitis C virus is strongly influenced by structure and target site accessibility. Chem Biol. (2010) May; 17 (5):515-527.

Sagan SM and Sarnow P. Plasmacytoid dendritic cells as guardians in hepatitis C virus-infected liver. Proc Natl Acad Sci U S A (2010) Apr; 107 (17): 7625-7626.

Lyn RL, KennedyDC, SaganSM, Blais DR,RouleauY, Pegoraro A, Xie XS, Stolow Aand Pezacki JP. Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism. Virology (2009) Nov; 394 (1): 130-142.

Koukiekolo R, Jakubek ZJ, Cheng J, Sagan SM, Pezacki JP. Studies of a viral suppressor of RNA silencing p19-CFP fusion protein: a FRET-based probe for sensing double-stranded fluorophore tagged small RNAs. Biophys Chem. (2009) Aug; 43 (3):166-169.

Cheng J, Koukiekolo R, Kieliszkiewicz K, Sagan SM, and Pezacki JP. Cysteine residues of Carnation Italian ringspot virus p19 suppressor of RNA silencing maintain global structural integrity and stability for siRNA binding. Biochim. Biophys Acta. (2009) Aug; 1794 (8):1197-1203.

Pezacki JP, Sagan SM, Tonary AM, Rouleau Y, Belanger S, Supekova L, and Su AI. Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. BMC Chem. Biol. (2009) 16(9):2.

Davis M, Sagan SM, Pezacki JP, Evans DJ, and Simmonds P. Bioinformatic and Physical Characterisation of Genome-Scale Ordered RNA Structure (GORS) in Mammalian RNA Viruses. J. Virol. (2008) Sep; 82 (23):11824-11836.

Cheng J, Sagan SM, Jakubek Z, and Pezacki JP. Studies of the Interaction of the Viral Suppressor of RNA silencing Protein p19 with Small RNAs Using Fluorescence Polarization. Biochemistry. (2008) Aug; 47(31):8130-8138.

Cheng J, Sagan SM, Assem N, Koukiekolo R, Goto NK, and Pezacki JP. Stabilized recombinant suppressors of RNA silencing: Functional effects of linking monomers of Carnation Italian Ringspot virus p19. Biochim. Biophys. Acta. (2007) Dec; 1774 (12):1528-1535.

Koukiekolo R, Sagan SM, and Pezacki JP. Effects of pH and salt concentration on the siRNA binding actitivy of the RNA silencing suppressor protein p19. FEBS Lett. (2007) Jun; 581 (16):3051-3056.

Sagan SM, Koukiekolo R, Rodgers E, Goto NK, and Pezacki JP. Inhibition of siRNA binding to a p19 viral suppressor of RNA silencing by cysteine alkylation. Angew. Chem. Int. Ed. Engl. (2007) 46 (12):2005-2009.

Sagan SM, Rouleau Y, Leggiado C, Supekova L, Schultz PG, Su AI, and Pezacki JP. The Influence of Cholesterol and Lipid Metabolism on Host Cell Structure and Hepatitis C Virus Replication. Biochem. Cell Biol. (2006) Feb; 84 (1):67-69.

Rakic B, Sagan SM, Noestheden M, Belanger S, Nan X, Evans CL, Xie XS, and Pezacki JP. Peroxisome Proliferator-activated Receptor α/γ Antagonism Inhibits Hepatitis C Virus Replication Through Post-transcriptional Effects. Chem. Biol. (2006) Jan; 13 (1):23-30.